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One of the keys to running a successful clinical trial is the selection of high quality clinical sites, i.e., sites that are able to enroll patients quickly, engage them on an ongoing basis to prevent drop-out, and execute the trial in strict accordance to the clinical protocol.
EKH and TBB will execute the trial and participate in the implementation.
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The selection of outcomes in pragmatic trials should be relevant for decision making and feasible in terms of executing the trial in the context of interest.
The Abacha regime drew international condemnation in late 1995 when Ken Saro-Wiwa, a prominent writer, and eight other human-rights activists were executed; the trial was condemned by human-rights groups and led to Nigeria's suspension from the Commonwealth of Nations.
KH will be executing the trial together with MIJ.
Reducing uncertainty quickly and inexpensively is the goal that drives the Chorus process, which consists of defining what data are required to change the probability of success, designing the simplest clinical trials that will provide such data, executing the trials cost-effectively, evaluating the data objectively, and delivering a recommendation to either continue or terminate development.
The authors' responsibilities were as follows: CD, JleC, SD: designed the study; PCR and CB: organized and executed the trials; SD, CD and JleC: interpreted the data, wrote and edited the manuscript.
All authors designed and executed the experimental trial.
The trial was designed, planned, and executed by the trial steering committee in collaboration with the UK Medical Research Council.
After 12 s of the Plan phase, a 0.5-s auditory beep cued participants to immediately execute the planned action, initiating the Execute phase of the trial.
CSB and PA designed and executed the original randomized trial.
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