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Among AKTs downstream targets is the tumor suppressor gene TP53 (HGNC:11998), a transcription factor that integrates information from many different types of cellular stress, and execute downstream responses appropriate for the given input [16].
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Taken together, these studies suggest that Sin3 complexes are involved both in programming gene expression that is dependent on intercellular signalling activities and in maintaining long-term cell fate decisions which are executed downstream or independently of such signals.
Results from MCA and the predictability study led to the suggestion that in contrast to network modifications executed downstream from the XA pathway, overexpression of XR or XDH positively affected the maximal flux capacity of UG.
Productive lipid signaling requires an orchestrated coupling between lipid metabolism, lipid organization and the action of protein machines that execute appropriate downstream reactions.
You may decide to ignore AI until it comes to your door and then you execute a downstream decision about AI.
Activation of caspase-2 alone is insufficient to execute all the downstream processes necessary for apoptosis.
Alternatively, LIN-12 could execute two different downstream pathways, one required for vulval morphogenesis and the other required for muscle arm development.
By interacting with structural and signaling proteins, Vav1 may serve to integrate signals required to properly execute activation of downstream pathways.
Many signaling proteins and transcription factors that induce and pattern organs have been identified, but relatively few of the downstream effectors that execute morphogenesis programs.
Transcription factors (TF) link stress signals to the downstream genes that execute cellular defense processes [ 20].
As a result, Syk-mediated phosphorylation of several adaptor proteins causes activation of downstream pathways, which execute phagocytosis.
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