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Fig. 5 Schematic model of ICG excretory defect.
Here, we report the association between ICG excretory defect and the expression of OATPs and NTCPs.
Therefore, we diagnosed the patient with HCC with an ICG excretory defect, and considered major hepatectomy.
However, in patients with an ICG excretory defect, the results of ICG tests become unreliable.
Several cases of hepatectomy in patients with ICG excretory defect have been reported, but the expression of hepatic transporters involved in ICG excretory defect has not been examined in these cases.
Although there are several previous reports of hepatectomy in patients with an ICG excretory defect, we believe that this is the first case of HCC with an excretory defect in which the expression of hepatic transporters was examined.
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First, we showed that C. elegans takes up Mn readily and is sensitive to Mn exposure, exhibiting developmental delay, excretory cell and osmoregulatory defects which can be related to kidney and bladder defects observed in rodents [83], [84] and man [44].
Data on the prevalence of renal disease in pSS comes from two sources; retrospective studies looking for overt renal dysfunction, mainly defects in excretory renal function and proteinuria [ 5, 12, 13], and smaller prospective series in which tubular defects were explicitly screened for [ 3, 14– 16].
Upper tract urothelial tumours are usually diagnosed as radiolucent filling defects on excretory or retrograde urography.
In the excretory phase small nodular filling defects or predominantly smooth narrowing of the renal pelvis and ureter are noted, so that misinterpretation as pyeloureteritis cystica, pyonephrosis or transitional cell carcinoma may occur.
Animals lacking the activity of both lin-12 and glp-1 arrest as L1 larvae due to defects in the excretory system and rectum, both derived from the AB lineage (Lambie and Kimble 1991).
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