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We show that the contactin RIG-6 is involved in excretory cell (EC) tubular elongation.
Loss of the excretory cell was the likely cause of death, since dying worms exhibited the characteristic rod-like phenotype (Fig. 3F&G) inherent to excretory-cell defective mutants [64] and excretory-cell ablated worms [65].
We previously found that a gtl-2 transcriptional reporter was expressed in the excretory cell [9].
A third worm TRPM channel appears to function in Mg2+ homeostasis in the excretory cell [17].
Expression is prominent in the excretory cell (Figure 1 A,h), a long H-shaped cell implicated in fluid balance.
The excretory cell expresses GTL-2 on its basal membrane, and this permits uptake of Mg2+ into the cytoplasm.
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Special excretory cells located on either side of the mouth and the larval heart disappear when the veliger leaves the plankton and metamorphoses into a crawling snail.
Unusually, the protonephridia do not take the form of flame cells, but, instead, the excretory cells consist of a skirt surrounding a series of cytoplasmic rods that in turn enclose a central flagellum.
C. elegans harbors a gastrointestinal tract, a reproductive system, epithelial, neural, muscle, excretory cells, and even innate immunity pathways [43].
In wild type excretory cells, we observed a small outwardly-rectifying current using the whole-cell configuration (its reversal potential [Erev] = 26.9+/−1.8 mV in Figure 3A and C); this current appears to be voltage-modulated, which is also observed with TRPM4b and TRPM5 as well as with GON-2 [17] (see Materials and Methods for details).
Excretory cells (renette cells) were banana-shaped and situated ventrally to the intestine.
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