Endometrial receptivity is probably not determined exclusively by the expression of selective adhesion molecules, and a series of cytoskeletal rearrangements is also likely to be important.
Relying exclusively on the expression of a single gene (ESR1) or genes which are co-regulated with ESR1 may have at least three limitations.
Palladin was previously shown to contribute to the invasive motility of human breast cancer cell lines, in a study that focused exclusively on the expression of 85 90 kDa palladin [15].
Furthermore, incubation of different cancer cells with recombinant Hepatocyte growth factor (recHGF) or Transforming growth factor-β1 (recTGF-β1), respectively, both known to promote metastasis [30], [31], exclusively increased the expression of FL-L1CAM.
Earlier studies deduced that MLL1 exclusively regulated the expression of homeotic genes and proper segmental identity in mammals [ 28, 42].
Other studies examining this question have either focused exclusively on the expression of a small number of cell adhesion receptors, or have studied non-human epithelial cells.
Many studies have, however, focused exclusively on the expression of the basement membrane molecule laminin, which is usually absent in high-grade neoplastic breast cancer cells [ 23, 24].
On the other side, HIF-1α exclusively stimulates the expression of several glycolytic enzymes, whereas the embryonic transcription factors Oct-4, cyclin D1, and EPO are upregulated under hypoxia in a HIF-2α-dependent manner [10 15].
However, our finding that the four qrr promoters are affected to different extents by each individual feedback loop could indicate that there exist conditions in which it is beneficial for V. cholerae to exclusively increase the expression of one particular Qrr sRNA.
EBV infects B cells and epithelial cells mainly in a latent form with spontaneous lytic activation, whereas the viral infection in EBV-associated tumors including NPC and EBVaGC is exclusively latent with the expression of only a few latent genes [2].
