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About 90% of matched antipsychotic users were exclusively prescribed an atypical antipsychotic medication, and, of these, 556 were exclusively prescribed quetiapine, 166 olanzapine, and 112 risperidone.
In Germany, biologic therapies for the treatment of RA are almost exclusively prescribed by rheumatologists.
Trimethoprim and nitrofurantoin are almost exclusively prescribed for UTI, thus UTI was the assumed indication for these prescriptions.
Endocrine treatment is exclusively prescribed to patients with luminal breast tumors that comprise approximately 70%% of all breast cancer cases.
Finally, it should be noted that nasal corticosteroids are not exclusively prescribed for allergic disease, but can also be prescribed e.g. for nasal polyposis.
Owing to the small number of subjects who were exclusively prescribed either amiloride or hydrochlorothiazide (0.7 and 0.4%, respectively), it was difficult to compute their separate effects.
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One possible solution is cluster randomisation[ 6], where one group of caregivers exclusively prescribes the experimental treatment and another exclusively the reference treatment.
As SSRIs were the most commonly prescribed antidepressants in the study population, absolute risks were estimated for women prescribed each individual SSRI drug alone (fluoxetine, citalopram, paroxetine, sertraline, and escitalopram), apart from fluvoxamine, which was only prescribed exclusively to 22 women.
LTRA as monotherapy was excluded because montelukast alone is prescribed almost exclusively for allergic rhinitis control.
APs and antidementia drugs prescribed exclusively by hospital specialists are not completely recorded in CPRD.
Again, there were few cases who were prescribed exclusively one of these drugs; but as with SCC, the IRR was increased for prescription of amiloride only (IRR=1.21; 95% CI: 0.39 3.74), but not for hydrochlorothiazide only (IRR=0.87; 95% CI: 0.45 1.68).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com