In contrast to the proteomic analyses, we found that UBE3A exclusively interacts with the S5a subunit, and no interaction with the other subunits was observed.
Nevertheless, this is most likely the case, as NaPi-2a almost exclusively interacts with other proteins through its PDZ-binding domain, and the PDZ interacting proteins are the same as other membrane proteins with similar carboxy ends (see below, the CFTR case).
SENP3, as a nucleolar protein, preferentially, nevertheless not exclusively, interacts with nuclear proteins (Drag and Salvesen, 2008; Gong and Yeh, 2006; Han et al., 2010; Hickey et al., 2012; Huang et al., 2009; Mukhopadhyay and Dasso, 2007; Yan et al., 2010), and has increased levels in various cancer tissues (Han et al., 2010; Hickey et al., 2012).
FOS contains an IR (IR_17) that competitively interacts with multiple partners (JUN, JUNB, JUND, or ATF2), as well as an IR (IR_435) that exclusively interacts with one partner (Figure 3B, right).
Also, WDR9(2) and EP300 exclusively interacted with the triply modified H3 pT3K4acK9ac peptide.
Moreover, the MeCP2 point mutant K464R exclusively interacts with SIRT1 (Fig. S2A ).
Conversely, the nuclear protein XAF1 exclusively interacts with XIAP, restraining this IAP anti-apoptotic action even in healthy cells.
Clearly, whereas Bcl-2 exclusively interacts with the central domain of the IP3R, Bcl-Xl seems to interact with the C-terminal tail of the IP3R.
