A Chinese study examining oesophageal squamous cell carcinomas (SQCs) showed that only 9% out of 35 HPV-16-positive specimens exclusively harboured the episomal form, whereas the remaining 91% contained either only the integrated form (6%) or a mixture of episomal and integrated forms of viral molecules (86%).
A. lamarcki, the only species observed to harbour multiple symbiont profiles, showed a marked zonation, with colonies at 10 and 25 m depth harbouring either P3 (n = 34) or P4 (n = 36), whereas colonies (>40 m) exclusively harboured P4 (n = 33).
This region is connected to the hydrophobic substrate binding C-terminal domain positioned in the upper part of the model, which exclusively harbours the clustered helical amino acid stretches depicted in Fig. 2.
DIPG exclusively harbours K27M mutations, but in histone H3.1 as well as H3.3 genes [ 8, 20, 56, 59, 60].
However, our results suggest that coronal slices through the most posterior EC exclusively harbour the human homologue of the rodent MEC.
The N-14, N-17, M-2, and C-4 classes are plant specific, the N-13 subfamily exclusively harbours yeast members and only mammals contribute to a special class of C-terminal kinesins (C-2) as well as to the N-15 kinesins.
Only nine of the 140 associated loci exclusively harbour variants within coding regions of genes (IL23R, GPR35, CD6, MUC19, GPR65, ZNF831, ADAM30, NOD2, FUT2) while an additional 13 have variants encompassing both coding and noncoding regions (UBQLN4, ITLN1, FCGRA2A, MST1/BSN, SLC22A4, REV3L, CARD9, ZPBP2/GSDMB, TUBD1, CD226, YDJC, ATG16L1, LACC1).
Acropora millepora colonies from MI harboured exclusively type D Symbiodinium (GenBank Accession EU024793), whereas coral colonies from Orpheus Island contained only type C2 Symbiodinium (GenBank Accession AF380552) [sensu 64].
These genes were thought for many years to be harboured exclusively by animal cells [ 3] but in the last decade several studies reported their presence in organisms that are not related to the Metazoa, including a basal fungal taxa (Blastocladiella emersooni); [ 3- 5].
Using a HS-numb line, we overexpressed Numb at defined moments during the life of the secondary precursor cells and we determined the proportion of transformed organs harbouring exclusively inner cells as a function of the time of HS application (Supporting data Fig. S5).
The results of two phase III Japanese trials comparing gefitinib and chemotherapy as first-line treatment in NSCLC patients exclusively with tumours harbouring EGFR mutations confirmed improved outcomes with EGFR TKIs (Maemondo et al, 2010; Mitsudomi et al, 2010).
