No extended signals were seen for probes flanking the Snrpn Ube3a locus, 5′ of Snrpn and at or 3′ of Atp10a (Fig. 1E and F, green fluorescence), suggesting that this region's highly differential chromatin organization exclusively encompasses the neuron specific poly-cistronic transcript produced only from the paternally inherited allele (17).
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In this model, the catalytic requirements for ligation are encompassed exclusively in the C-lobe, its thioester-linked Ub, and the substrate.
We have used a phylogenetically heterogeneous set of ten monophyletic lineages of water beetles (Table 1) occurring in the western Palearctic, some with both lotic and lentic species, and others encompassing exclusively either lotic or lentic species.
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The enzyme displayed a substrate preference that was shifted from exclusively double-stranded DNA in the presence of magnesium to also encompass significant activity against single-stranded DNA when calcium was added.
The first cluster, composed of 53 isolates exclusively coming from Bordelais, encompassed the highest proportion of repeated genotypes (G/N = 0.81) and was the less diverse (genic diversity He = 0.414, mean number of alleles per locus na = 3.5).
18 NEW YORK/REGION 33-37 Plans to Rebuild Manhattan Expand to Entire Downtown Plans for the rebuilding of Lower Manhattan, until now focused almost exclusively on the World Trade Center site, have for the first time expanded to encompass all of downtown.
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