This suggests an effect of the inhibitors already during the initiation of differentiation as MHC exclusively stains differentiated myoblasts already expressing myofibrillar proteins.
The Dll3 and Jag2 genes are expressed in differentiating neurons [10], [11], with Jag2 being expressed exclusively in differentiating motoneurons [11].
In agreement, dkk1b promoter elements drive gene expression exclusively in differentiating osteoblasts near the amputation site (Kang et al., 2013).
The expression levels of five NAC genes including PNAC070, 086, 121 and 122 were peaked exclusively in differentiating xylems supported by two independent microarray datasets [ 87, 88].
However, Park et al. reported that in the absence of TGF-β supplementation, MSCs on soft substrates did not differentiate exclusively to chondrocytes, but also differentiated to adipocytes, generating a heterogeneous population.
Human decidua parietalis stem cells (hdpPSC) were found to differentiate exclusively and rapidly towards neural cells on the collagen CNT matrix.
The derived colonies of the vole cells by visual microscopic analysis reveal a flat, epithelial morphology with tight, intercellular contacts, a high nuclear/cytoplasmic ratio, they maintain multipotency after prolonged culturing in vitro and differentiate exclusively into derivatives of trophoblast lineages.
In all other intermediate hosts, however, bradyzoites differentiate exclusively to tachyzoites, and disseminate extraintestinally to many cell types.
Alternatively, WT CICs may relate to the more committed nephron progenitor cells, a population shown to self-renew and differentiate exclusively to nephron epithelia throughout nephrogenesis, fulfilling the criteria of a true committed stem cell (Kobayashi et al, 2008).
These NMP-like cells were also shown to efficiently differentiate exclusively into paraxial mesoderm and posterior neurectoderm both in vitro and in vivo upon grafting into cultured mouse and chick embryos suggesting an NM bipotent character.
