Like GlnRS, GluRS2 exclusively charges tRNAGln[ 4, 5].
This platform is almost exclusively positively charged (Figure 2C) and thus well suited to bind the polyanionic substrate polySia.
In addition to peptides #3, #5 and #6, peptide #4 significantly reduced the uptake of the exclusively negatively charged In-minigastrin as well.
In contrast, the solvent exposed side of the helix contains almost exclusively large, charged residues (Arg392, Glu395, Arg396, Glu399, Arg402, Glu404).
It admitted yesterday that it is talking to Barr Laboratories, the generic drug firm trying to invalidate Shire's patent on the drug and therefore the right to make it exclusively and charge a high price.
The FTC, aided by chipmaker Intel and iPhone vendor Apple, filed suit two years ago, accusing Qualcomm of forcing customers like Apple to work with it exclusively and charging excessive licensing fees for its technology.
We also assumed a "very low emission" scenario where EVs are charged exclusively from renewable sources.
Chick-fil-A, which has long enjoyed a reputation as a fundamentally Christian company and insists on closing all of its locations on Sundays so employees can go to church, made headlines earlier this month when Cathy gave an interview with the Baptist Press saying he was "guilty as charged" in exclusively supporting the traditional definition of marriage.
We speculate that some negatively charged proteins, exclusively present in the nuclear membrane and firmly bound to the envelope, may provide the necessary electrostatic potential to attract and stabilize the protein shield.
The primase binding surface of NTD of BstDnaB is exclusively covered by negatively charged side chains at center that must be aiding a strong binding with the CTD of BstDnaG, which is rich in positively charged side chains on the of helicase binding surface.
