Sentence examples for exclusively activated from inspiring English sources
For instance, it has been observed using a combination of glutamate binding-deficient and G protein coupling-deficient receptors that the mGlu1 receptor triggers Gq-coupled signalling through cis- and trans-activation, while Gi/o and Gs are exclusively activated through cis-activation (Tateyama and Kubo 2011).
However, FGF18 exclusively activated FGFR3 without detectable activation of FGFR1.
To evaluate the relevance of the CB1 receptor in the physiological control of striatal BDNF expression, we selectively manipulated MSN activity by the designer receptor exclusively activated by designer drug (DREADD) pharmacogenetic technique.
We then used this paradigm to test the effect of modulating activity in the NAc using the Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) hM3Dq and hM4Di.
Kotz is also applying the pharmacogenetic DREADD (designer receptor exclusively activated by designer drugs) approach to define orexin action for physical activity energy expenditure.
An extreme case of target selectivity is found for the peroxisome proliferator-activated receptor gamma (PPARγ), an intracellular target of LPA that is exclusively activated by unsaturated acyl species of LPA (Tsukahara et al., 2006).
Here, we report that FGF23 exclusively activates FGFR4 on cardiac myocytes to stimulate phospholipase Cγ/calcineurin/nuclear factor of activated T cell signaling.
While the constructs used in the experiment are widely accepted as generally implicating left versus right activity, neither the RFFT nor the COWAT can be said to exclusively activate a given hemisphere.
We reasoned that enhanced Map3k4 expression in P38α−/− cells exclusively activates JNK due to lack of competition from P38α.
Our data confirmed that the antioxidant ethoxyquin (EQ) and the isothiolcyanate sulfurophane (SFP) exclusively activate the antioxidant response element (ARE), and thus represent monofunctional inducers.
Therefore, to exclusively activate Erk2 without affecting other signaling pathways, K562 sensitive cells were stably transfected with an exogenous constitutively active MEK1.
