Median distances greater than 12 kb were measured for those sets of promoters with mutually exclusive modifications as well.
In view of these results and those of other authors [19], we propose a novel mechanistic model for USP25m regulation in which the same lysine residue can be either ubiquitinated or sumoylated, and these mutually exclusive modifications have opposite effects on the enzyme activity.
However, acetylation and methylation of H2AZ are mutually exclusive modifications.
Mass spectrometric analysis detected the presence of H3S28ph on monomethylated and dimethylated H3K27, but not on trimethylated H3K27 peptides, suggesting that H3K27me3 and H3S28ph are mutually exclusive modifications and that phosphorylation of H3S28 precludes the trimethylation of H3K27.
Epigenetic memory systems have been predicted to involve mutually exclusive histone modifications that, through positive feedback mechanisms, generate bistable states [ 1, 2].
This key sentence was modified in the last (definitive) edition of the Origin of Species as follows: "Furthermore, I am convinced that Natural Selection has been the most important, but not the exclusive, means of modification" (Darwin 1872a, p. 22).
I am fully convinced that species are not immutable; but … are lineal descendants of some other and generally extinct species….Furthermore, I am convinced that Natural Selection has been the main, but not the exclusive means of modification" (Darwin 1859, p. 7).
Receptor PTMs could be monitored by a set of PTM-recognizing domains, e.g., SH2, 14-3-3 14-3-3 14-3-3ng for idetc.ficallowing exclusive or simultaneous modiforatidentification
The transporting capabilities of CNTs, along with the appropriate surface modification and exclusive physicochemical properties, holds great potential in the field of drug delivery.
