Sentence examples for exclusive alterations from inspiring English sources

MEMo automatically identifies mutually exclusive alterations targeting frequently altered genes that are likely to belong to the same pathway.

However, these are not mutually exclusive alterations, appearing together in multiple tumors.

Conversely, mutually exclusive alterations observed in the two DIPG subgroups may influence the response to a given targeted agent.

We identified multiple rare, but mutually exclusive, alterations targeting components of these complexes, as well as ANKRD11, an inhibitor of p160 co-activator complexes.

This suggests that scenarios exist, potentially induced by treatment, where co-activation of otherwise mutually exclusive alterations is selected for as potential resistance mechanisms.

Finally, an unbiased pathway analysis revealed multiple rare, but mutually exclusive, alterations linked to loss of activity of co-repressor complexes N-Cor and SMRT.

For example, the mutually exclusive alteration of genes in a pathway is a characteristic of cancer drivers [ 5, 6, 47].

In the pathway analysis section, the authors present a network, discovered by searching for mutually exclusive alteration patterns.

They are associated with two mutually exclusive genetic alterations, TP53 alterations and 1p/19q co-deletions [ 6, 62] that respectively characterize astrocytic and oligodendroglial IDH-mutant gliomas.

The concept of cooperative and mutually exclusive genetic alterations has rarely been examined at the level of CNAs or on a genome-wide scale.

After a subnetwork passes the significance test, the following step is performed to evaluate whether it exhibits a pattern of mutually exclusive genomic alterations.