Sentence examples for exclusive alteration from inspiring English sources

In the pathway analysis section, the authors present a network, discovered by searching for mutually exclusive alteration patterns.

For example, the mutually exclusive alteration of genes in a pathway is a characteristic of cancer drivers [ 5, 6, 47].

MEMo automatically identifies mutually exclusive alterations targeting frequently altered genes that are likely to belong to the same pathway.

However, these are not mutually exclusive alterations, appearing together in multiple tumors.

Conversely, mutually exclusive alterations observed in the two DIPG subgroups may influence the response to a given targeted agent.

We identified multiple rare, but mutually exclusive, alterations targeting components of these complexes, as well as ANKRD11, an inhibitor of p160 co-activator complexes.

This suggests that scenarios exist, potentially induced by treatment, where co-activation of otherwise mutually exclusive alterations is selected for as potential resistance mechanisms.

Finally, an unbiased pathway analysis revealed multiple rare, but mutually exclusive, alterations linked to loss of activity of co-repressor complexes N-Cor and SMRT.

A built-in Gitools option sorts genes and samples within a heatmap to present the pattern of mutually exclusive alterations, which is one approach to visual exploration of driver genes that are involved in the same pathway [ 48].

Given TERTp-mut is associated with both 1p19q codeletion and EGFR amplification, which are mutually exclusive alterations with opposite prognostic effects and TERTp-mut had a different effect in low- and high-grade gliomas, prompted us to refine our survival analysis.

They are associated with two mutually exclusive genetic alterations, TP53 alterations and 1p/19q co-deletions [ 6, 62] that respectively characterize astrocytic and oligodendroglial IDH-mutant gliomas.