This consideration also typically necessitates minimizing false positive tests, through exclusion of variants of uncertain significance (VUS).
All ACSL amino acid sequences retrieved in the database mining were initially aligned in MAFFT alignment software using default parameters [ 35] and manually curated with the exclusion of regions of uncertain homology, gaps, and of partial sequences.
A total of 4,056 patients were positive for NoV. After exclusion of patients with uncertain hospitalization status, 3,848 patients were included for further analysis (Table 1).
Exclusion of data points with uncertain S and F values (n = 29) gave very similar results in terms of the significant covariates and their coefficients (Intercept = −1.37, F = 1.81, SS = −1.68).
The abstracts were reviewed according to the inclusion criteria; if the inclusion or exclusion of an article was uncertain when reviewing the abstract, the full article was reviewed thereafter.
The changes in proportions diagnosed at each stage were tested with and without exclusion of cases with unknown stage (uncertain or not recorded).
Only autosomal SNP were considered in this study, leading to the exclusion of all SNP with an uncertain map position on build 10 of the pig genome sequence, as well as SNP on the sex chromosomes (M non-autosomal = 9308).
Vulnerability denotes pastoralists' lack of resilience to the occurrences of uncertain events: droughts, livestock diseases, exclusion from markets, resource scarcity in the form of marginalised access or rangeland degradation (Rass 2006).
Both are present to a major degree in sample splitting, in which the model is more uncertain because of the exclusion of cases for validation, and the validation is more uncertain because of the exclusion of cases for generating the model.
Exclusion criteria include patients receiving combination chemotherapy before the resection of operable liver metastases (patients of uncertain operability are eligible), brain metastases, prior adjuvant chemotherapy with oxaliplatin and uncontrolled medical co-morbidity likely to compromise treatment.
