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Evaluation of response by TWSTRS, tolerance and CGI improvement alone (ie, exclusion of duration of effect) established 58.3% (95% CI 53.1% to 63.4%) of subjects as responders.
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6 9 Considering three primary endpoints, that is with the exclusion of the duration of effect criterion, approximately 60% of patients achieved response.
Factor analysis has also been performed in 171 non-diabetic controls, utilizing the same variables as in type 1 diabetic individuals, except for serum fasting insulin in place of insulin dose to account for the role of hyperinsulinemia/IR and the exclusion of diabetes duration, which has no correlate parameter in non-diabetic individuals.
Exclusion of language or duration variables did not change the qualitative results.
Currently, brief protocol summaries, including aims, primary outcomes, inclusion and exclusion criteria, duration of the trial, and planned intervention, of all clinical trials are available on the internet.
We addressed this by repeating tests of interaction between treatment effect and components of methodological quality or length of follow-up after the exclusion of trials with a duration of dual antiplatelet therapy of less than six months and found no evidence for an interaction in any of these analyses (data available on request).
The ten most intensive precursor ions were dynamically selected in the order of highest intensity to lowest intensity and subjected to collision-induced dissociation using a normalized collision energy setting of 35% and a dynamic exclusion duration of 1 min. The heated capillary was maintained at 200°C, while the ESI voltage was kept at 2.2 kV.
MS/MS spectra were acquired in LTQ using a data-dependent acquisition procedure with a cyclic series of a full scan followed by MS/MS scans of 20 of the most intense ions with a repeat count of 2 and a dynamic exclusion duration of 30 s.
Even after exclusion of the very low acquisition durations (<5 min), the duration of acquisition remained an independent predictor of late H/M.
That standoff was resolved with a temporary exclusion of cultural goods -- the duration of which is likely to become a matter of dispute again as the give-and-take proceeds on access to each other's markets.
As for other phase I/II clinical trials, limitations of this study include its small sample size, limited duration, and exclusion of patients with severe RA.
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