Sentence examples for exclusion of compounds from inspiring English sources

The exclusion of compounds for some assays regarding this problem could be beneficial for the performance of multi-target methods.

Subsequent exclusion of compounds with off target effects such as outer- or inner membrane permeabilization identified compounds 7c, 7g, 12c, 12i and 13g as efflux pump inhibitors (EPIs).

The obtained results, which are comparable with or exceed those, published by other teams for the given biological activities, allow one to use proposed approach as an efficient filter for exclusion of compounds with undesirable activities on early stages of drug design process.

In this case, exclusion of compounds which were identified by the prediction software as outside of the prediction space was found to result in an improvement in the calculated model performance values, indicating that the prediction software accurately identified the limits of its predictive ranges.

Also, exclusion of compounds proving false-negative in sub-optimal test systems could be prevented by using suitable test systems for the detection of potential cardiotoxicity.

However, most cases required further purification by column chromatography (silica gel, 90:10:1 EtOAc MeOH TEA) with TEA to facilitate elution and to remove trace impurities with the exclusion of compound 7. Purification of 7 by column chromatography using various solvent systems only led to rapid decomposition and then a string of unidentifiable spots from the eluent appeared in TLC.

For large sets, this can take several hours resulting in fatigue and unintentional exclusion of attractive compounds that fall late in the list.

The narrowness of site SFcav led to a systematic exclusion of larger compounds, which explains the low enrichment observed.

The Mdr1a/1b Brcp1 mouse model has been used to assess the contribution of BBB ABC-transporters to exclusion of lipophilic compounds from the brain [50].

The exclusion of a compound used in almost a third of the patients therefore might have distorted our results.

A tree trained using this definition contained many of the substructures present in the original tree and was similarly predictive of activity in independent assays despite the exclusion of 75% of compounds defined as active under the more permissive definition of activity (Fig. S9).