On the one hand, in the absence of prior studies that have investigated this potential bias, our results suggest that such exclusions might be unnecessary.
In such circumstances a simple approach is to consider sensitivity analyses where some or all of these trials are excluded but simply discarding entire trials is rather extreme and various combinations of exclusions might be contemplated in this procedure.
"If you can't do control to the point of exclusion, you might be throwing good money after bad".
The exclusion zones might be based on the noise from the airport operation, areas affected by aircraft landing pattern, and areas that would interfere with airport radar [20].
But even if the vast majority of politically active, federal-government-loathing assault-rifle owners have no interest in starting their own private war, focusing on the sane majority to the exclusion of others might be downplaying some real danger.
Although our exclusion of BMS might be perceived as a limitation, methodological and conceptual reasons dictated such a choice.
'...to an extent I would see it as a diagnosis, possibly of exclusion, that perhaps might be arrived at after various sort of acute, or acute on chronic, conditions had been excluded, treated, eliminated if you like.... pain... without, an organic basis, or with no demonstrable underlying physical pathology and that's kind of my working definition of it.' (GP 21).
Classical mechanisms of B cell tolerance that have been demonstrated in the mouse such as follicular exclusion might also be impaired in patients with SLE due to lower FcγRIIb expression [48] or due to diminished competition from a non-autoreactive B cell population [49].
But it was possible, over much of the past decade, to believe that a few of the old demons of suspicion and exclusion might finally be laid to rest.
