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Pathogens identified in patient samplesψ (excluding ventilator filers samples).
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(As we've reported, many states have been quietly laying plans for such a scenario. For example, Florida has considered excluding certain patients from ventilators). .
The authors concluded that quantitative cultures are not suitable to confirm or exclude clinically diagnosed ventilator associated pneumonia.
26 As a secondary analysis, we repeated all analyses using a subset of the entire dataset excluding patients with complete missing ventilator data required for measuring the primary exposure to compare with results from the primary analysis using multiple imputation for missing data.
22 In sensitivity analyses, we assessed the impact of excluding quasi-randomised trials on mortality and ventilator associated pneumonia.
Patients on ventilators who were transferred in were also excluded due to unknown ventilator time.
Respiratory complications were defined as: development of acute respiratory distress syndrome [ 17]; ventilator-associated pneumonia [ 18]; or initiation of mechanical ventilation after 3 ICU days, excluding cases of reintubation resulting from extubation failure.
For the secondary analysis of complete data, 30 (6%) of the 485 eligible patients were excluded owing to missing ventilator variables required for measuring the primary exposure, leaving 455 patients with 4938 eligible ventilator settings and 10 321 total ventilator settings.
Patients were also excluded if they were ventilator dependent in the respiratory wards or received negative pressure or high frequency oscillatory ventilation due to their chronic respiratory failure and/or receipt of uncommon mode of ventilation.
Similarly, after excluding the Grecu et al. [ 62] study because the authors reported only ventilator-associated pneumonia (VAP), the same effect was shown (RR = 0.65; 95% CI, 0.44 to 0.94; P = 0.02; heterogeneity I = 0%).
They reported the results of a study evaluating patient ventilator interactions in a group of patients with moderate to severe ALI/ARDS, excluding those patients with known chronic obstructive lung disease.
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