Yet, analysis of PD excludes the likely events of cells undergoing apoptosis, necrosis or loss during passaging.
For its limited power, this study does not exclude the likely role also played by alloimmunity (13) and autoimmunity (14) in islet graft decline.
Sorrell warned that 2013 would be another demanding year, with slow or stagnant growth in western continental Europe (excluding the UK) likely to continue for some time.
However, our results are based on data excluding the most likely erroneous observations [ 23], and any remaining erroneous observations in the data seem unlikely to be different across races, and thus unlikely to affect the overall pattern of our results.
We used the clonal isolates to identify persistent SNPs, and the different series to identify those persistent SNPs that recurred within the same ORFs, thereby focusing the analysis on a small number of loci where the identified variants are more likely to be adaptive and excluding the substantial background of likely neutral variation that hitchhike along with selective beneficial mutations.
However, we did not exclude the less likely possibility that the binding of other proteins to syntaxin, e.g., the binding of Munc 18 to assembled SANRE complexes containing syntaxin in the "open" conformation ([28] or Munc −13 which stabilizes the "open" conformation of syntaxin [29], [30], could be impaired and result in inhibition of Ca2+-triggered secretion.
However, in this mixed chimera system, we cannot exclude the equally likely possibility that CD28− T cells are simply less fit than CD28+ T cells and are outcompeted.
For over a decade now, well-heeled Indians, and those joining their ranks, have built walls around themselves, excluding the poor – those most likely to suffer from malaria and TB, diseases all but extinct in first-world India's imagination – with a brutality unmatched in any part of the democratic world.
Excluding the very elderly has likely overestimated the dominance of the coronary events at the expense of the brain events, as would the associated elective admissions for the diagnostic (eg, stress testing, coronary angiography) and coronary revascularisation procedures.
GCM used with more than 3 clusters also included the necrotic area, because the large number of clusters, inadequate for such a homogeneous tumour (when excluding the necrotic centre), makes it likely to add low uptake regions to the tumour.
