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Note that excluding the interaction term of group with time, results in a parallel line model, (i.e. the differences between groups are identical at each point of measurement).
It should be mentioned that the simulation only included DNA damage, which may not be the only target in the cell and furthermore, it accounted only for direct interaction between the radiation and the NPs, thus excluding the interaction between NPs and secondary species, as described above.
Likelihood ratio tests were conducted between nested models that included and excluded each variable; however, main effects were tested for significance only after excluding the interaction term.
Third, the regression output based on Eq. 16 is presented, but now including the effect of mortalities, while excluding the interaction between time and mortalities.
Excluding the interaction terms allows the mapping-models to be used in situations where only one or two of the VAS scores are measured.
Having demonstrated significance of the full model, we checked for significance of the interaction term by comparing the fit of the full model with that of the reduced version (excluding the interaction term) using an LRT.
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All subsequent analyses reported in this paper are performed by excluding the interactions of level 4. Evidently, the interactions attracting most confidence belong to level 1, which have been verified at least twice; whereas, levels 2 and 3 include interactions assigned moderate confidence, which have been verified by one source and are additionally supported by phylogeny.
When these are excluded the interaction term for Hispanics is positive and statistically significant.
Finally, our isolated hMVEC model precluded measuring hyperoxic effects mediated by the interaction between endothelial cells, leukocytes, and vascular smooth muscle cells and excluded the interaction with flow and circulating mediators.
When interactions between feedback conditions and phase were found non-significant, ANOVA was run again to exclude the interaction term.
When older individuals were excluded, the interaction in ARIC was similar to that in the other studies.
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