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In summary, 39 articles were identified (excluding systematic reviews and retrospective studies), with 1703 patients.
Excluding systematic errors (i.e. errors due to an initially faulty implementation of chemotherapy protocols into computerized dictionaries) from the analysis, the error rate decreased to 8%.
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We also excluded systematic reviews and editorials, as well as studies not written in English, and those that were not AD- or dementia-specific in their focus.
We excluded systematic reviews focusing on a specific setting, except when this setting concerned developing countries (e.g., intervention for tobacco cessation in a dental setting) or a specific population (e.g., tobacco cessation for hospitalised patients).
We also excluded systematic reviews of prevention or treatment of complications of HIV infection (e.g., opportunistic infections, Kaposi's sarcoma) and those evaluating an intervention for another disease among subjects infected with HIV (e.g., treatment of anaemia or tuberculosis infection in people with HIV infection).
***This excludes systematic reviews of qualitative evidence that require a different approach to quality appraisal.
To exclude systematic errors due to grid artefacts, all computations were performed on different grids.
We also excluded systematic reviews of diagnostic test accuracy, prognosis, economics evaluations, qualitative studies and non-randomised studies.
DNA from each biological repeat was evaluated both at increasing and decreasing sites to exclude systematic bias in DNA preparation.
We excluded systematic reviews/meta-analyses of therapies and drug interventions, and of specific disease or health conditions.
However, our analyses tended to exclude systematic overestimation of Φd that could have affected the study's conclusion.
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CEO of Professional Science Editing for Scientists @ prosciediting.com