We re-counted these numbers by further excluding scenarios 0.3 & 0.4 and 0.4 & 0.5, because they represent minimal levels of clinically meaningful difference in the response rate between doses, and thus may be of less relevance than other scenarios.
As a second step, GLM and HP were applied to those scenarios for which extinction times were available (i.e., excluding scenarios for which one or several trajectories were non extinct after 1,000,000 generations) to examine variations in the ratios of extinction times (e.g., T D/ T G) and their relationships with ecological variables.
The decreasing ratio of imine 10 to amine 4 over time is in accordance with mechanistic scenario 2 in which the reaction occurs at the imine, not at the amine, and excludes scenario 1.
We excluded scenarios 0.1 & 0.2 and 0.2 & 0.2 because it is unclear which conclusion should be deemed 'correct' in these scenarios.
We chose this early time period in attempt to exclude scenarios where preliminary microbiologic data were available (e.g. knowledge of whether the organism was a lactose-fermenter) since this may have influenced antimicrobial choice.
To condense the results and to facilitate interpretations, we excluded scenarios based on large isolation distances (>800 m) from the figures, as they only continue trends but do not provide additional information.
Although at present we cannot exclude scenarios of an ancient origin of ES-mediated protein import into plastids [ 9, 137], our results clearly favor a 'late' model by demonstrating that αAmy3, αAmy7, NPP1, and CAH1 were redirected to green plant plastids fairly recently.
There is no objective argument for excluding this scenario from the analyses, for all but the last period the effect of including or removing the CSM3 driven scenario was however neglible.
Yet, excluding any scenario of historical allopatry is impossible for most taxa [76], so that the most convincing cases of sympatric speciation have been limited to unique isolated terrestrial and freshwater settings, such as a crater lake [77] and a remote oceanic island [78].
Most mice that rejected Ptgs1/Ptgs2 −/− cells were resistant to a subsequent challenge with unmodified parental BrafV600E melanoma cells, implying the development of immunity to shared target antigens and excluding a scenario of cancer immune privilege driven locally by tumor-derived prostanoids.
