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Participants will be advised to avoid consuming large amounts of dietary ginger or additional ginger capsules as well as any other adjuvant or alternative therapy for nausea and vomiting (excluding prescribed anti-emetic medication) during the study period.
At the screening, patients will be informed that if they consume large amounts of dietary ginger or additional ginger capsules, as well as any other adjuvant or alternative therapy for nausea and vomiting (excluding prescribed anti-emetic medication), that this should be stopped at least 1 week prior to chemotherapy.
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Additional use of urine dipstick to exclude prescribing of nitrofurantoin for patients with alkaline urine (often resulting from an infection with Proteus spp. for which nitrofurantoin would be considered inappropriate treatment) could further increase the appropriateness of treatment of UTI with nitrofurantoin ([ 15].
Drug use referred to psychotropic substances such as cannabis, ecstasy and ketamine, but excluding drugs prescribed by doctors.
We excluded patients without a valid postcode related Townsend deprivation score, and existing users of anticoagulants by excluding those prescribed anticoagulants in the 180 days before their study entry date.
We also performed sensitivity analyses to minimize misclassification of prevalent cases by increasing the washout period from 3 to 5 years and excluding patients prescribed an immunosuppressant within 3 months of the index date.
Because this is a proof-of-concept study and the use of antibiotics may confound the mechanisms underpinning the synbiotic therapy, sensitivity analyses will be undertaken including and excluding patients prescribed antibiotics during either intervention arm.
Age at first insulin prescription, sex, number of unique other drugs used in the year before start of insulin (excluding those prescribed for diabetes), number of hospitalisations in the year before start of insulin and calendar time were considered potential confounders or effect modifiers.
We excluded patients prescribed apixaban owing to the small sample size.
A sensitivity analysis excluded supplements prescribed in the year prior to diagnosis.
Because of the small number of prescriptions for monoamine oxidase inhibitors, we excluded patients prescribed these drugs from further analysis.
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