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Then the procedure was the same as above, excluding one trial and repeating until each trial has been excluded once.
We identified 18 trials (2225 participants, excluding one trial as the number of participants is unknown [ 26]) eligible for inclusion at the full paper review stage (Fig. 1).
A sensitivity analysis excluding one trial (36) gave significant results (OR 2.07 [95% CI 1.16 3.69]) with no evidence of heterogeneity (I = 0%) or publication bias (P = 0.37).
The POR calculated through sequentially excluding one trial from the analysis ranged from POR 0.55 (0.39 – 0.78) when Miller 2012 was excluded to POR 0.69 (0.44 – 1.08) when Miller 2010, the largest trial, was excluded (Table 3).
Sensitivity analysis by excluding one trial did not significantly change the results of adverse events (RR = 1.05, 95% CI: 0.84 to 1.32, P = 0.44; P for heterogeneity = 0.17, I2 = 36%).
Similar(55)
We excluded one trial from the analysis (Leigh Brown 1997).
We excluded one trial (Ryu 2013) from the review.
Among these, we also excluded one trial because its definition of TRD did not meet our criterion [ 33].
14 We excluded one trial as a clear outlier, but the proportion of excluded patients was small and had little effect on our effect estimates.
We excluded one trial [ 17] because it investigated only patients with mild hypoxemia and had a very short follow-up of only 3 days, and another trial [ 18] which turned out to be a subgroup analysis of a larger included trial [ 8] [see Additional file 1].
A sensitivity analysis that excluded one trial of three arms [ 16] in which fewer than 75% of participants completed the trial resulted in a smaller effect size, with HbA1c 0.96% lower (95% CI 0.47, 1.45) corresponding to 11 mmol/mol in the sulfonylurea-treated groups than in the comparator groups.
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