However, exclusion protocols relating to morbidities in other body systems are applied for different reasons, and can reduce the availability of important knowledge about the action of the new drug in patients who have those excluded morbidities.
Once exclusions are applied in an RCT, for whatever reason, this removes the possibility of gathering evidence on how the new drug will act in patients who, for example, suffer from one or more of the excluded morbidities, and/or who take one or more of the excluded medications.
When excluding co-morbidity diagnosed within 90 days before the ovarian cancer diagnosis, only the risk of liver and pancreatic disease (OR=1.4) was statistically significant elevated (Table 2).
In this study, the use of allogenic resurfacing material showed promise for reducing post-operative pain as well as for excluding donor site morbidity that is observed when using autografts [ 23].
We excluded co-morbidities from the Charlson index that were already captured by the PSI variable discussed above, including neoplastic disease, renal failure, hepatic disease, congestive heart failure and cerebrovascular disease.
Single agent or two drug regimens with fluoropyrimidines are recommended for patients presenting with non-resectable and/or asymptomatic disease, and/or co-morbidity, excluding from intensive first line chemotherapy or later surgery [ 9].
Collectively, these results provide preliminary evidence for biological plausibility of PM-related health effects in individuals with COPD and suggest that respiratory morbidities, excluding asthma, may also increase the susceptibility of a population to PM-related respiratory effects.
Generally, a post-resection remnant liver of less than 30%, unfavourable location of metastases, co-morbidities excluding major surgery, aggressive tumour biology, and/or presence of extrahepatic disease are regarded as limitations for liver surgery.
However, results were similar for maternal and perinatal morbidity after excluding maternal or perinatal death (data no shown).
The analysis was performed from a Swedish societal perspective, including costs related to productivity losses due to morbidity but excluding productivity losses due to mortality.
