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Trolox, an alkyl-peroxyl free radical scavenger, had no effect (Fig. 1J), excluding involvement of lipoperoxidation.
They attribute these to corresponding changes in INa, λ and therefore arrhythmic substrate while not excluding involvement of triggered activity in initiating arrhythmia with either genotype.
Similarly, the prior administration of ODQ (10 μM), a well known inhibitor of soluble guanylate cyclase (sGC), did not affect the induction of apoptosis (Fig. 4b), excluding involvement of sGC, and confirmed the findings previously reported for other classes of NO-donors.
While not excluding involvement of other signalling pathways and ER stress, we propose that upregulation of BMP signalling, caused in at least some cases by altered endocytic BMPR traffic, is an important candidate pathological component of the axonal degeneration seen in the endosomal group of HSPs, and may be relevant in other conditions showing distal axonopathy.
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The superficial fascia of underlying musculoskeletal structures should be identified to exclude involvement of deeper structures.
The synthesis method is of high novelty as it excludes involvement of any hazardous chemical and complicated laboratory set up.
High-resolution CT and thin-section MRI (Fig. 9) are essential for preoperative surgical planning, and they must be performed to exclude involvement of the paranasal sinuses and intracranial extension [49].
A tumor-negative SLN virtually excludes involvement of the regional lymphatics.
Tagging with monomeric L221K YFP variant was incorporated to exclude involvement of the dimerizing capacity of the YFP portion [9].
Magnetic resonance imaging (MRI) excluded involvement of intracranial tissues.
In all cases a preoperative bone scintigraphy excluded involvement of the stem.
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