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Grip strength comparisons were repeated after excluding frail participants.
To test whether the association with grip strength was driven by the association with frailty, we assessed grip strength after excluding frail participants.
The inverse relationship between the C allele and grip strength persisted after excluding frail participants, indicating that the mt204 association with grip strength was not solely a product of its association with frailty (Table S4).
Again, the observed association was more pronounced in males, but was consistent across the entire CHS population and remained even after excluding frail individuals to minimize the potential for bias due to initial selection methods.
Clinical trials in dementia should consider not excluding frail older adults, as frailty appears to drive disease expression and might be needed for the classic neuropathology of dementia to express its deleterious effects.
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As an adjunct to general and cancer-specific diagnostic procedures, the comprehensive geriatric assessment (CGA) was used at the study entry to identify and exclude frail elderly patients.
This is especially relevant to elderly patients as the clinical trials underpinning many drug therapies exclude frail and elderly patients, thus, creating significant uncertainty around the effects of pharmacotherapy in elderly patients [ 23, 24].
Because most manufacturer-based researches exclude frail elderly, and as such the appropriate dose for such patients, the prescription of split tablets may be the result of oversedation observed with whole tablets.
In the present investigation, the CGA was not included in the study plan, however, specific criteria to exclude frail elderly patients, together with the accurate monitoring of sideeffects and general measures for minimising toxicity allowed the safe and successful administration of combination chemotherapy in a population of patients whose median age was 76 years.
Given that earlier definitions have tended to exclude frail older adults, this strategy pays particular attention to the translation of the active-ageing concept to situations of dependency by centring on three key principles: fostering adaptability, supporting the maintenance of emotionally close relationships and removing structural barriers related to age or dependency.
A limitation of this study is that only subjects attending the research center performed the 2 × 15 m walking test, possibly excluding more frail individuals and introducing a floor effect on parameters related to this test.
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