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Median actual olaparib treatment duration (excluding dose interruptions) was 168.0 days (range 50 to 389) in cohort 1 and 151.0 days (range 57 to 243) in cohort 2. Median dose intensity (total dose received/total dose planned) of olaparib was 100% (cohort 1 range 86 to 100%; cohort 2 range 80 to 100%) in both cohorts.
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Figure 5 shows trends in SP, ACT, and all antimalaria treatments over time regardless of whether they met national guidelines, but excluding doses of SP given for IPTp.
In order to reduce the influence of a small number of outlier doses that were very delayed, the analysis was repeated excluding doses that were ≥23 months late for 4 and 6 month schedule points and ≥19 months late for 12 and 18 month schedule points.
We excluded dose or schedule comparisons of the same antibiotics.
a The two-phase and linear models are fitted to subsets of the 0 – 20 mSv liver data with latency φ = 36.90 years (optimal for the two-phase model on the 0 – 20 mSv data, see Table 3) b Ri is the excluded dose range (in 10 mSv units).
To counter this effect when performing our logistic fits, we excluded doses at which the observed activity decreased relative to lower doses (Table 1, Figure 3).
We excluded dose-ranging studies, comparisons of two different formulations of the same method and studies in which subjects in one or more treatment arm received several different methods of labour induction.
The failure of total prescription dose to render statistical significance in the Cox proportional hazard model as well as its weak coefficient of determination with PV dosing excluded prescription dose applied to the tumor volume as a possible explanation of our data.
Excluding the dose received by this patient, the mean (SD) and range for the high-dose rectal group becomes 33.0(4.7) mg/kg and 27.2 43.4 mg/kg respectively.
A neuropathic pain treatment was defined as an analgesic (excluding low dose aspirin), an anaesthetic (oral or intravenous), an antiepileptic with no history of epilepsy, or an antidepressant.
A secondary evidence network of drug class was also constructed, to compare the effects of direct thrombin inhibitors (dabigatran and ximelagatran), direct Xa inhibitors (rivaroxaban and apixaban), VKA (excluding low dose), ASA 100 mg daily, and placebo or observation.
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CEO of Professional Science Editing for Scientists @ prosciediting.com