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It binds molecular oxygen more than 10,000 fold stronger than vertebrate myoglobin [ 16], excluding a function in O2 transport.
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This does not exclude a function of cIAP-2 in chlamydial lung infection since both may be organized in functional complexes [15].
However, we do not exclude the possibility that this pathway might be activated by other forms of stress nor do we exclude a function for CHIP-dependent degradation of HIF-1α under physiological or pathophysiological conditions.
Although these data exclude a stationary MutS that remains bound at the mismatch during the reaction, they do not exclude a function for MutS-induced DNA loops that had been observed using electron microscopy [ 46].
Urinary and blood work up excluded a functioning adrenal adenoma.
They require additional imaging such as unenhanced/chemical-shift MRI to determine whether or not the lesion is a lipid-rich adenoma, in addition to biochemical evaluation to exclude a functioning lesion/mass.
Moreover, loss of function of Phlda2 had no significant consequence for these organ weights, excluding a reciprocal function for Phlda2 in regulating organ weights.
Although not excluding a possible function of biochemical cues, three lines of evidence suggest a primary role of mechanical signals in the process.
Although certainly not excluding a secondary effector function for lymphocytes in SpA or for macrophages in RA synovitis, these findings point towards distinct pathogenetic mechanisms in the two diseases and fit well with the hypothesis that SpA synovitis is primarly driven by innate immune cells with secondary alterations in lymphocyte activation and functions [ 28].
These results do not however exclude a possible function for SMG-1 in sensory perception.
Since we could exclude a discernible function of Plrx in blood stage development we extended our phenotypic analysis to the entire Plasmodium life cycle (Table 2).
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