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The figure excludes site development, another major trend.
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This statement excludes sites like Amazon and other high-traffic e-commerce platforms.
Among the 1210 introns, median length was 122 bp (average length 232 bp; this excludes sites overlapping alignment gaps).
Our analysis region excludes sites where NA19129 is not a homozygous reference (for region of interest (ROI), see Additional file 1: Table S1).
Additionally, patient data was evaluated between sites to exclude site bias.
The resulting scheme is then used to classify the previously excluded site.
The complete dataset and the dataset excluding site DE-RUGEN were both run.
However the strength of this study is that it is multicenter excluding site bias and representing the real world situation.
Without the 16 patients treated at the excluded site, 445 randomised patients were available for efficacy analyses, 304 of whom were also receiving MTX at baseline.
The misclassification in Site 4 adds noise to the analysis, therefore, we excluded Site 4 from the main analysis; sensitivity results showed that the findings held when Site 4 was included albeit with attenuated effect sizes for infectious disease testing.
Accumulated mutational analyses revealed that the main site 86 (helix II), as well as other sites in helices I to III (excluding site 89), play crucial roles in the spectral tuning of UV-sensitive cone opsins (SWS1 opsin) [ 46, 47].
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