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This method excludes closely related terminal taxa because the Yule tree prior does not include a model of coalescence, which can complicate rate estimation for closely related sequences [ 69].
This method excludes closely related terminal taxa because the Yule tree prior (see below) does not include a model of coalescence, which can complicate rate estimation for closely related sequences [ 113].
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Within each lineage, we selected a representative subset of genomes that excludes closely-related strains and species and which is most suitable for comparative analysis using the RegPredict tool [ 36].
We identified 301 SNPs located at least 100 bp apart between the 2 genomes (we excluded closely located SNPs), among which, 102 were called as positive by Nimblegen algorithm, detecting only 33.9% of the SNPs.
9 This latex agglutination assay could be valuable in correctly identifying select agents and excluding closely related Burkholderia species that cause similar disease in humans.
Yang et al. [ 8] suggested excluding closely related individuals from the analysis when estimating genetic variation captured by all the SNPs, using a GRM-cutoff option.
For example, in medical genetics it is used for excluding closely related individuals from association studies and thereby to avoid inflated false positive rates.
The results of disease-free survival, where the 11 cases of contralateral breast cancer as first event were excluded, closely mirrored those of EFS analyses (data not shown).
A 10-cM window was used to exclude closely linked cofactors, and the number of control markers was set at five (the default program setting).
This effect can be reduced using a general linear model (GLM) to estimate the proportion of genes identical by descent between any pair of individuals and excluding closely related individuals [ 18, 19].
In order to efficiently search for sets of significant SNP, we preliminarily pruned SNP, and excluded closely linked SNP having r2 > 0.95 in sliding 50 SNP windows using PLINK [ 26].
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