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Eligible patients were those with advanced disease (stage I excluded) undergoing induction chemotherapy, and with available material.
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Trial A excluded patients undergoing obstetric procedures from inclusion.
We therefore excluded patients undergoing peripheral vascular interventions or EVAR.
Dysmorphophobic and psychologically unstable persons were also excluded from undergoing injection augmentation.
The study excluded patients undergoing preventive treatment of recurrent ankle sprains.
We also excluded cases undergoing maintenance peritoneal dialysis because of the small number of these cases (n = 769).
Finally, we excluded patients undergoing peripheral vascular interventions, EVAR or neuro-interventions from our study for reasons explained above.
As we excluded patients undergoing endovascular therapy, our results are only generalizable to patients receiving IVT without subsequent endovascular therapy.
The initial protocol excluded patients undergoing any dialysis, but it was subsequently amended to remove this restriction to facilitate recruitment.
We excluded patients undergoing intra-arterial thrombolytic therapy or interventional embolectomy (fig 1) and patients with missing modified Rankin score at discharge.
The study included a mix of low risk, moderate risk, and high risk patients, but excluded those undergoing percutaneous coronary interventions.
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