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We excluded type 1 diabetes patients (N = 1567), because they are treated primarily by specialists.
First, we identified that type AB is genetically heterogeneous, so we excluded type AB for further analyses.
This gave us 2 alternative models, where some of the covariates could be excluded (type of incision, choice of fixation, diagnosis, and comorbidity).
In doing so we inevitably also excluded type 2 diabetes patients treated with an intensive insulin scheme, accounting for about a quarter of the type 2 patients treated with insulin in 2003 (personal communication ND, IPH).
Furthermore, not all studies distinguished between diabetes type 1 and 2. Most of the studies excluded type 1 diabetes as a diagnosis of diabetes before 30 years of age.
The selection of those target genes excluded type II fatty acid synthesis (FAS II) because P. falciparum mutants lacking FAS II enzymes fail to generate sporozoites inside the oocyst, indicating that the FAS II pathway is essential for sporogony (van Schaijk et al., 2013).
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Where possible, we excluded types of heterotypic synonyms (see Supplementary Figure S1), as explained in following curation steps.
Of these, 13 excluded intellectual disability as a reason for involuntary treatment, 11 excluded substance misuse, and 3 excluded types of personality disorder.
Amino acid sequences of murine members of the cystatin protein family (including Type 1, Stefins; Type 2, Cystatins; but excluding Type 3, Kininogens) were collected using NCBI's Entrez Gene database [21].
Though the frequency of rs17578796 resembles that of the reported in Europeans by dbSNP NCBI), its low frequency highlight the requirement for additional genotyping of independent samples to exclude type I error.
Furthermore, we cannot exclude type I errors.
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