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For this reason, most analyses excluded Trial 1.
They excluded trial arms with sub-therapeutic doses (<800 mg/day of chondroitin and <1500 mg/day of glucosamine, in accordance with doses licensed in Europe).
The patient's GP will be notified in writing regarding the patient's participation and will also be provided with a list of excluded trial medications (table 1).
Online supplementary appendix table 2 lists additional SAEs for the 10 excluded trial summaries with trial completion dates in 2009 or later.
We excluded trial protocols that were withdrawn prior to the beginning of study enrolment; non-randomized trials; duplicate registry entries; and studies where the trial registry listed a study completion date after 31 December 2008.
We will also explore the potential effects of participant withdrawals by conducting a sensitivity analysis, where excluded trial participants are first added back into the analysis as having experienced the outcome and second as not experiencing the outcome.
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Therefore, we excluded trials before the tenth trial from our results as training trials.
For the ICU LOS outcome, we excluded trials that did not directly report SDs.
Lastly for the DMV outcome, we excluded trials that did not directly report SDs and trials that did not stratify randomization by mechanical ventilation.
The more recent review by van Beijsterveldt et al. [24] excluded trials using injury- or joint-specific exercises and reviewed the efficacy of generic exercise interventions.
We excluded trials that were confounded by adjunctive treatments i.e. when lithium was combined with another treatment such as an antidepressant or anticonvulsant.
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