Exact(9)
Normal S100 values excluded severe cerebral damage.
The more restrictive and specific case definitions excluded severe events and almost halved the 28 day case fatality when compared to broader and more sensitive definitions.
Patients with the following criteria were also excluded: severe valve disease, congenital disease, complete atrioventricular block, sick sinus syndrome, pericardial disease, primary pulmonary hypertension, and pulmonary artery embolism.
Women with the following contraindications to the use of NRT will be excluded: severe cardiovascular disease, unstable angina, cardiac arrhythmias, recent cerebrovascular accident or TIA, chronic generalized skin disorders or known sensitivity to nicotine patches, chemical dependence/alcohol addiction problems.
Patients with the following complications were excluded: severe pulmonary fibrosis, with functional vital capacity below 70%; left-sided heart disease; chronic thrombotic or embolic disease; renal failure, including a history of scleroderma renal crisis; hypertension; and diabetes.
Furthermore we found that the most specific case definition, which restricted to specific bleed codes from both datasets, excluded severe cases and resulted in a lower 28 day case fatality.
Similar(51)
The authors did exclude severe injuries from their population, but were unable to adjust for injury severity within their sample.
Conclusion: In patients with unstable angina in class IIIB according to Braunwald classification, the negative cardiac troponin test did not exclude severe coronary artery disease, which in the majority of patients required revascularization without any additional non-invasive testing for ischemia.
Cortical rim is absent excluding severe hydrocephalus and confirming hydranencephaly.
A cutoff value of >28 mg/dl provided a sensitivity of 84.6% but a rather low specificity of 60.0% in excluding severe hyperkalemia >6.0 mmol/l (AUC = 0.75).
However, none of these signs had very good negative likelihood ratios, meaning that they were not useful for excluding severe dehydration in children.
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