Although we did not accurately count the number of those who were excluded in this registry, we speculate that a less than 5% of the new CKD stage 2 5 patients were excluded due to the exclusion criteria.
In addition, confounding by indication, although controlled, cannot be excluded in registries, and we found significant heterogeneity between observational studies on clopidogrel, which may limit conclusions.
The registry contains information on prescribed and sold drugs since 1994 excluding in-hospital drug use [ 19].
Patients with shorter observation intervals (that is, less than 3 years between ICU admission and the date of inquiry at the registry office) were excluded in analyses of long-term mortality.
Patients with shorter observation intervals, that is less than two years between ICU admission and date of inquiry at the registry office, were excluded in analyses on long-term mortality.
Thus, patients who urgently needed treatment because of their conditions were included in the registry, but would have been excluded in a controlled clinical trial.
Individuals unable to give consent as a result of mental, intellectual, or cognitive deficits are excluded, however, such could appear in the Registry through collection of family history data but without collection of bio-samples from them.
There were 1365 incident end-stage renal disease patients age ≤ 21 years (excluding province of Quebec) identified in the registry for the interval between 1992 and 2007, and 1200 888%) health card numbers were available for linkage.
Patients in the registry were excluded if they met ACR criteria for SLE.
