Excluding feasibility and cost-effectiveness, all outcomes were assessed at baseline (week 0), post-intervention (week 12) and follow-up (week 24), and all assessments preceded intervention exposure.
A list of 185 schools with at least 20 pupils at the fifth grade was provided by the Regional Education Service (schools with less than 20 pupils were excluded for feasibility reasons).
Although similarities were found towards exposure and outcomes in the present systematic review, the heterogeneity of studies regarding design, population and type of exposure and outcome measures excluded the feasibility of any quantitative meta-analysis.
When clinically insignificant cancer also was taken into account (excluding one feasibility trial that evaluated safety rather than ablation), 4 50% of men had positive biopsy results after treatment (n = 255).
Four patients randomized to CVVH were excluded from the feasibility analysis, two due to death prior to commencement of study RRT, and two due to receipt of continuous venovenous hemodiafiltration as the initial mode of therapy.
Items on the School Functioning Scale were excluded from the feasibility analysis for the 2 to 4 age subgroups given that toddlers do not necessarily attend school or daycare and thus, depending on whether their child was enrolled in school or daycare, parent proxy respondents were given the option of completing the School Functioning items.
However, resource and feasibility limitations excluded these possibilities.
Reviews that were restricted to clinical outcomes, psychosocial outcomes, acceptability, cost-effectiveness or feasibility were excluded from this overview, unless data relating to healthcare utilisation could be extracted.
CRS patients with nasal polyposis were not excluded because this was a feasibility study intended to determine procedure feasibility across a broadly representative population, which would include patients with polyp disease.
13 One way to proceed is to adopt a user-focused approach to design: establishing and refining the content of a draft measure in consultation with patients and practitioners, making decisions as to what to include or exclude based on feasibility and the end-users' priorities for use, and finalising the measure's content and format following pilot testing in specific contexts.
