The association between adverse events and default may be overestimated, and we were sufficiently concerned to exclude adverse events a priori from our multivariate model.
Thus, this definition excludes adverse events due to drug quality, administration with no indications, and off-label use.
The range of conditions included in these codes are listed in Table 1 and excludes adverse drug reactions.
Prior to being admitted to the feline practice in February 2004, both cats had been treated twice with ivermectin and several times with corticosteroids and fed an elimination diet to exclude adverse food reactions without relief.
Therefore, we did not exclude adverse drug event codes that were coded in secondary diagnosis fields in order to avoid underestimating the sensitivity of the administrative dataset and the ICD-10 code set.
These stratified analyses may have lacked power to definitively exclude adverse reactions as a risk factor for death, however, we believe that differences between the two causes of interruption make this distinction plausible.
However, it must be emphasised that evidence of lack of harm (however robust) is not the same as unequivocal evidence of safety, which requires studies on up to tens of thousands of subjects to confidently exclude adverse effects that are subtle or involve rare outcomes.
In terms of the latter, the circumstances in which the PAC is unreliable do not apply to this patient; the fact that she was ventilated and was on inotropes without improvement mandates hemodynamic monitoring to exclude adverse effects of these interventions.
Although only a few types have been experimentally characterized, bioinformatic analyses of the presumed contents of diverse BMCs suggest that the shell serves to protect the cell from toxic compounds generated by the encapsulated enzymes, prevent the loss of volatile intermediates, and/or exclude adverse competing substrates or enzymes.
Nonetheless, restricting the presence of an ICD-10 code up to the tertiary and secondary diagnoses fields for inpatient and outpatients, respectively may have introduced some selection bias, for example by excluding adverse treatment events such as neutropenic sepsis and radiation proctitis.
