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This approach has excluded adequate consideration of the psycho-social influences that have a substantial impact on patients' decision-making processes and disregards our growing understanding of health as a state of physical, mental, and social well-being [ 43].
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However, the surgical group in both studies had more pain and worse functional scores at baseline, which excludes adequate outcome comparison.
Therefore, leukemia as the underlying cause was excluded before adequate treatment for CSS could be started.
In total, 55 patients were included; 5 patients were excluded because adequate images could not be obtained.
In premenopausal women, pregnancy was excluded and adequate contraception was required for the duration of treatment and follow-up.
Patients were excluded if adequate follow-up was not possible (environmental or geographic difficulties, no compliance to undergo necessary clinical-instrumental investigations, etc).
Furthermore, cervical spine instability in these patients is often not confirmed or excluded by adequate radiographic examination[ 10] and functional clinical testing and cervical spine stability may not be preserved in the deeply anesthetized patient with neuromuscular blockade.
Since the range of mean values within the samples must be small, we exclude an adequate number of the probe sets below the maximum expression, where the density of the probe sets per unit of expression is low (see the identity test below).
Patients diagnosed after 2006 were excluded to ensure adequate duration of follow-up.
We excluded cases if adequate paraffin-embedded tumor tissue was not available at the time of this study.
Finally, we also excluded participants without adequate follow-up after baseline, including 59 survivors who did not develop diabetes, but were missing at the final examination at year 7, and 41 participants who did not develop diabetes, died during follow-up, and missed the clinical visit within 1 year of death (because we could not determine whether they developed diabetes).
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