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However, for DOGMA, we do not have access to the code and consequently can not exclude the query sequence from the backend database in the test.
Exclude the query string from the URL.
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Each active is used as a reference for searching against the whole dataset (actives plus decoys) for this target, excluding the query active to avoid an artificial boost in performance.
The search conditions enrichment factor calculation procedure were chosen to reproduce those described for the previous benchmarking [11]; through conducting the searches using the lowest energy conformer of each active, while excluding the query active from the results, followed by the calculation of the averaged enrichment factor for all actives.
It should be emphasized that we have excluded the query sequence itself from the reference database in the test.
At the same time we keep track of data provenance by putting the Reactome data in a separate namespace, so that we can either include or exclude the Reactome data from our queries.
112 genes with duplicated sequences were excluded from the query.
This includes that sentences mentioning ICD-10 codes in free text are excluded from the query episodes.
BLAST searches can recover high-score (low E-value) matches based solely on short regions of high similarity (including Stowaway TIRs), so searches were run twice; the TIR sequences were first included with, and then excluded from, the query sequences.
To exclude the possibility that protein synthesis inhibitors correlate strongly with many compounds, we next performed a reverse query with anisomycin.
In addition, to exclude the regulators that were involved with proliferation, we performed the MRA within the CLL networks using as query a PCNA proliferative gene signature [ 34].
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