It thus has a rudimentary stock of enzymes that seems to permit homologous recombination, SOS response and excision repair.
In contrast, ' Ca. P. mali' has an extended set of genes for homologous recombination, excision repair and SOS response than ' Ca. P. asteris'.
The amount of residual disease found following surgical excision represents the pathological response to the preoperative treatment and remains the most important prognostic factor.
While PARP1 is involved in base excision repair occurring in response to DNA damage [ 9], BARD1 functions in association with BRCA1 [ 10].
The locus includes a putative transcription factor Tfb2 (PFL2125c), a subunit of transcription/DNA repair factor TFIIH, that has been implicated in DNA damage response, nucleotide excision repair [ 71] and chromosome fragility [ 72].
Additionally, the examples of the SOS response, prophage excision, and relaxase function suggest targeting of these processes can potentially lead to the accumulation of toxic intermediates and cell death.
Furthermore, qPCR showed that most of the genes involved in the DNA damage response (nucleotide excision repair, mismatch repair, nonhomologous end-joining and homologous recombination) and chromosome maintenance were more strongly expressed in both zidovudine and tenofovir-exposed samples than in control samples (data not shown).
The pathways found to be integral to DNA damage response included Base excision repair, Nucleotide Excision Repair, Mismatch Repair, Homologous Recombination Repair, RecQ helicases, DNA damage response, Proteasome, Glutathione Synthesis, TOR pathway, Basal Transcription, Ribosome, ATPase, and Notch signaling pathway.
It was found that the triple knockout had nucleotide excision repair and checkpoint responses indistinguishable from those in p53 mutant cells.
Human WRN, a RecQ helicase encoded by the Werner syndrome gene, is implicated in genome maintenance, including replication, recombination, excision repair and DNA damage response.
