Like other regulatory GTPases, Rho requires GDP/GTP exchange dependent on guanine nucleotide exchange factors (GEFs) for its activation [ 5].
The first to apply this approach was the geneticist, Sewall Wright, who noticed that equations are symmetrical objects (i.e., they can be rewritten in order to exchange the dependent and the independent variables); therefore, Wright complemented equations with a "path diagram" [ 7].
The second, relatively new, class of agents is based on an effect called chemical exchange-dependent saturation transfer (CEST).
Glycosoaminoglycan concentration by chemical exchange-dependent saturation transfer (gagCEST) is a technique based on labile protons residing on the GAGs.
Both amide proton and hydroxyl protons from GAG have been shown to be suitable as chemical exchange-dependent saturation transfer agents, allowing the direct measurement of GAG content in vivo[ 49].
Our findings show that the post-asphyxia seizures are attributable to an enhanced Na/H exchange-dependent net extrusion of acid equivalents across the blood brain barrier and to consequent brain alkalosis.
Because of the technical pleading requirements peculiar to assumpsit, the inference was drawn, early on, that in an executory contract the exchanged promises were dependent in the making but independent in the performance stage, unless the parties had expressly agreed otherwise, with the result that the exchange relationship remained unprotected.
Takeuchi, K. et al. Identification and characterization of the slowly exchanging pH-dependent conformational rearrangement in KcsA.
To investigate the effect of climate on forest structure, we used parts of the same model but exchanged productivity as the dependent variable with the coefficient of variation of diameter at breast height.
Therefore, either the yeast glycolytic glyceraldehydes dehydrogenase must be exchanged against an NADP+ dependent enzyme (together with alcohol dehydrogenase) or the cofactor preference of Ilv5 must be changed to NADH.
