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Just two days ago, for instance, a stern-looking female officer, in the course of our brief interview, kept following up on most of my answers, in the fashion of a four-year-old, with an earnest "Why?" Why? Why?? Why??? This, more or less, is how the exchange unfolded: — Where are you going today? — New York City.
A more contentious exchange unfolded when Sanders called his rival the candidate of "the establishment," citing contributions that a super PAC supporting Clinton has received from Wall Street.
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"The collaborative experiment that was hypersalon set in motion so many amazing exhibitions and exchanges that unfolded in the past year.
Here we show that cysteine quenching dynamics also provide a novel method for measuring folding rates when the exchange between folded and unfolded states is faster than the unquenched triplet lifetime (∼100 μs).
Concurrent with compaction, the ensemble displays increased peak width of P values, possibly reflecting a reduction in the rate of conformational exchange among iso-energetic unfolded, but compact conformations.
By Macy Halford November 19, 2009 An amusing footnote to the exchange between Malcolm Gladwell and Steven Pinker that unfolded last week: someone anonymously purchased the domain name Igonvalue.com on the day Pinker's review of Gladwell's new book, "What the Dog Saw," a collection of essays first published in The New Yorker, ran in the Times.
It could be envisaged that the K-turns are initially relatively flexible in an exchange between folded and unfolded conformations, allowing the local RNA to explore tertiary contacts.
The DHFR structures are generally very similar except for the A−B loop region and part of helix B (residues 15−31) which could not be directly detected for L. casei apo DHFR because of line broadening from exchange between folded and unfolded forms.
However, native-state hydrogen exchange experiments detected a partially unfolded intermediate under native conditions.
In both cases, the exchange between the folded and unfolded states is apparently slow on the NMR time scale, consistent with an interconversion rate below ∼10 s–1.
Since the hydrogen-exchange assay provides insight into the presence of locally unfolded conformations under native conditions in exchange with the folded ones, smaller exchange rates correspond to slower local backbone dynamics [23], [24], [25], [26].
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