Exact(5)
In such a network each node, (for example an exchange in a telephone system) is responsible for relaying the signal that it receives to the next exchange towards a final destination.
Rab35 switch II glutamine 67 mutation to alanine (Q67A) greatly reduced DENND1-stimulated nucleotide exchange towards Rab35.
Similarly, the Q67A switch II mutation greatly reduced DrrA-mediated nucleotide exchange towards Rab1 from a kcat/Km of 6.0 × 10 to 5.3 × 10 M−10−10
Drug safety management might be further improved by extending patient data exchange towards other important parameters, such as medication allergies, platelet counts, electrolyte concentrations, international normalised ratio, liver enzymes and plasma drug levels.
In agreement with this idea, the switch II glutamine mutation Q67A that greatly reduced DrrA-mediated nucleotide exchange towards Rab1 had little effect on the activity of budding yeast TRAPP towards Rab1/Ypt1.
Similar(55)
Relying on these networks, China and Southeast Asian countries have built up mutual trust, cooperation and interdependence and allowed relevant parties to reach consensus in long-term exchanges, towards a relatively convergent value system.
As a suggestion, exchanges towards G-C/C-G pairs could improve ITS2 folding stability [ 72] when an organism is undergoing specialization to habitats with higher temperatures, and perhaps, the fast-evolving hCBC pathways (G-U/U-G → G-C/C-G) allow rapid ecological adaptation processes, in contrast to two-step CBC-type changes.
Furthermore, ZHP provides better selectivity of ion exchange membranes towards hardness ions [49].
The emerging paradigms of service-oriented computing and Cloud Computing put emphasis on services as a uniform and general information exchange interface towards end-users.
Thus we sought to determine whether the isolated Sec7 domain from Yel1 could display nucleotide exchange activity towards Arf3.
They demonstrated that Varp preferentially interacts with the GDP-bound form of Rab21 and has a stronger guanine nucleotide exchange activity towards Rab21 than Rab5, leading to the activation and endosomal localization of Rab21.
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