On the other hand, S0, the water-exposed C-terminal end of S1, and the water-exposed end of S2 were seen to be rapidly exchanged, indicative of exposure to water.
If this morbid exchange is indicative of Shriver's illusionless candor, it also points toward another one of her abiding preoccupations: the counterfactual.
It is more difficult to assess whether metabolite exchange is indicative of non-cell-autonomous metabolism, when exchange concerns metabolites that are needed by both exchange partners, amino acids, and nucleobases for instance.
Peptides within this region revealed bimodal exchange behavior, indicative of two distinct protein populations with slow interconversion and significantly different deuterium exchange kinetics (EX1 kinetics (Konermann, Pan, and Liu, 2011)), which might reflect bZIP LOV dissociation during labeling.
Okay, let's try it again!", and ultimately found the exchange funny and indicative of Rundgren's opinion of the band: "Todd was such a 'musician' while they were just getting by on attitude and energy.
This behavior corresponds to intermediate-to-slow exchange and is indicative of a conformational change or the existence of multiple states that interconvert slowly.
Such behavior exemplifies intermediate-to-slow exchange and is indicative of the existence of two states that interconvert slowly on the NMR timescale.
As discussed above, the β4 β5 loop in the FK1 domain of FKBP52 exhibits no evidence of conformational exchange line-broadening, indicative of motion in the microsecond millisecond timeframe.
It's only a quick 10-second exchange, but it's indicative of a larger relationship: Beneath all the reality TV insanity they're brother and sister -- and being at odds makes them uncomfortable.
Apart from the lost dispersion, the first SDS-induced state has significantly broadened signals, especially in the amide region (Fig. 1C) indicative conformational exchange on the µs-to-ms timescale.
