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They suggest that if levels are too high then dendritic spines will be excessively stable, impairing plasticity; likewise, if levels are too low then the spines will be very unstable, also hindering plasticity.
Phosphorylated eIF2 inhibits its own guanine nucleotide exchange factor, eIF2B, by forming an excessively stable eIF2∙eIF2B complex, thereby decreasing the level of active eIF2∙GTP in the cell (Hinnebusch et al., 2007).
The mutant phenotypes suggest that reduced ptCpn60 levels result in excessively stable FtsZ filaments, though whether this is through a direct effect on FtsZ or a regulator of FtsZ assembly, and whether the effects result from misfolding of some proteins in the mutant backgrounds or loss of another activity of ptCpn60, remain to be determined.
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"So not excessively excessive.
As a result the distribution of changes of free energy of folding,, is relatively unaffected by the stability, as long as the protein is not excessively (i.e., unrealistically) stable (Goldstein 2011), a conclusion that has been verified both by other simulations and experimental measurements (Bloom et al. 2005, 2006, 2007; Tokuriki et al. 2007).
However, it is not stable in plasma and is excessively glucuronidated both in the intestine and by first pass metabolism, which limits penetration into the brain [ 110, 119– 119].
The suspension works well enough to keep the bike stable while traversing bumps, but it is excessively harsh in comparison with models from competitors that come factory-equipped with premium forks and shock absorbers.
Body weight was stable for ≥3 months before the study, and no subject participated in an excessively heavy exercise program.
When the receptor accumulates excessively on the ER membrane, BiP shifts target from IRE1 α, and this results in the stable activation regardless of UFP.
Christoph Sebald, 25, from Germany, sees Europe as "stable, effective, and often successful," but admitted: "The EU is still a predominantly economic integration and favours elites excessively.
Everyone excessively tidy, excessively generous.
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