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Although it was reported that p62/SQSTM1 can assist in channelling substrates through the proteasomal degradation pathway, it also delays or reduces proteasomal degradation of short-lived proteins, including cell death regulator p53, when accumulating excessively as a consequence of autophagy inhibition.
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Here sequential super-stereotypy is manifest in a complex behavioral sequence that is instinctive and naturally stereotyped to begin with, but becomes even more stereotyped or excessively rigid as a consequence of the DAT mutation.
As a consequence, excessively released ULVWF multimers are more slowly cleared from the circulation and generate spontaneous formation of microvascular platelet thrombi responsible for multivisceral organ failure.
"The sense of threat arises as a consequence of (1) excessively negative appraisals of the trauma and/or its sequelae and (2) a disturbance of autobiographical memory characterized by poor elaboration and contextualization, strong associative memory and strong perceptual priming.
The DfT has admitted that it miscalculated the riskiness of FirstGroup's winning bid – which offered to pay the government £13.3bn over 15 years – and as a consequence had asked for an excessively small financial guarantee from the company.
As a consequence, helium is too cheap.
As a consequence, clinical uncertainty often results in suboptimal or excessively toxic treatments, which ultimately may lead to poorer outcomes as compared with younger patients (Dale, 2003; de Magalhães, 2013).
As a consequence, N.Y.U.
As a consequence, Taseer is dead.
As a consequence, the cell dies.
As a consequence, we got downgraded.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com