Sentence examples for excessively activate from inspiring English sources

In agreement with our data, soluble A β oligomers have been shown to excessively activate extrasynaptic NR2B-containing NMDARs in acute slice cultures, and activation of NR2B-containing NMDARs by A β in primary neurons resulted in a loss of synaptophysin- and PSD-95 signals.

For example, tissue injury can cause endothelial injuries associated with local and systematic inflammatory reactions; these reactions are important for the production of tissue factor and factor VII, which can excessively activate coagulation.

"They aren't selling just any commodity," says Kessler. "They've designed highly stimulating products, substances that excessively activate the reward circuits of the brain, and consumers come back for more".

However, if the stresses suddenly perturb to an acute level and the inflammatory responses still take a correspondingly sharp response to excessively activate the downstream reactions, the protective mechanisms will instead injure the organisms.

Collectively, these results suggest that WA led HRas-GTP accumulation to excessively activate the Ras/Raf/ERK/p53-p21 Ras/Raf/ERK/p53-p21ced apathways and G2/M arrest of human lung carcinoma cells.

Accumulating studies provide evidence for the connection between the dysregulated miRNA network and excessively activated TLR signaling in SLE, indicating the potential of miRNA as a novel SLE therapeutic108,109,110.

"The idea that evolution would permit the existence of mast cells in essentially all vertebrates cells, that when excessively activated by exposure to an otherwise harmless substance, could kill the host would appear to fly in the face of what evolution is supposed to do, right?" he asks.

NF-κB is excessively activated in many tumors, stimulating transcription of anti-apoptotic genes and cell cycle promoters.

In the presence of C1-INH deficiency, the classical complement pathway can be inappropriately or excessively activated [78].

However, when prooxidant capacity elevates to the level beyond some threshold antioxidant mechanisms are excessively activated and lower ROS levels will be observed.

The antioxidant system is persistently and excessively activated by the redox regulators and ROS generation is inhibited in the long term.